Clinical OMICS

JUL-AUG 2018

Healthcare magazine for research scientists, labs, pathologists, hospitals, cancer centers, physicians and biopharma companies providing news articles, expert interviews and videos about molecular diagnostics in precision medicine

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Page 13 of 51

12 Clinical OMICs July/August 2018 F or the first time, scientists have tracked the repair of DNA damage induced by the popular chemotherapy drug, cisplatin, at the whole-genome level in a mam- mal around the clock. Using single-nucleotide sequencing, the team of scientists lead by Nobel laureate Aziz Sancar, M.D., Ph.D., found that DNA repair of transcribed genes is controlled by two circadian programs in mouse tissue. The findings are a sig- nificant step toward a goal Sancar has been working toward for 15 years: developing mechanism-based cisplatin chronochemotherapy protocols that will reduce toxicity and tumor resistance in cancer patients. "This was the first time the repair of DNA damage caused in an animal was ana- lyzed at the whole-genome level at single-nucleotide resolution," says Sancar, a pro- fessor of biochemistry and biophysics at the University of North Carolina School of Medicine. Sancar is the senior author of the current study, which appeared in the May 7 issue of the Proceedings of the National Academy of Sciences. Sancar is hoping to reduce the negative impact cisplatin can have on cancer patients by taking advantage of the body's natural DNA repair clock, something scientists Camille Mojica Rey Contributing Editor Can Transcriptomics Help Find the Right Time to Administer Chemotherapy? On the CLOCK man_at_mouse / Getty Images

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