Clinical OMICS

SEP-OCT 2018

Healthcare magazine for research scientists, labs, pathologists, hospitals, cancer centers, physicians and biopharma companies providing news articles, expert interviews and videos about molecular diagnostics in precision medicine

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4 Clinical OMICs September/October 2018 News Vaping Tied to DNA Damage According to a preliminary study, vapers have higher levels of certain DNA-damaging compounds in their saliva. Worse, vapers sustain a kind of DNA damage that is consis- tent with these compounds. Evidence of DNA-damaging compounds and DNA damage was collected by scientists based at the Masonic Cancer Center at the University of Min- nesota (U of M). Led by Silvia Balbo, Ph.D., assistant professor at U of M, researchers examined the saliva of e-cigarette users and found unusually high quantities of three DNA-damaging com- pounds—the reactive carbonyls known as formaldehyde, acrolein, and methylglyoxal. Also, in comparisons of vapers and non-vapers, the scientists showed that the vapers had higher levels of DNA damage related to acrolein exposure. n Circadian Rhythms and Mood Disorders Genetically Linked A genome-wide association study (GWAS) by University of Glasgow researchers, in- volving data on more than 70,000 individ- uals in the U.K. Biobank, has identified a potential genetic link between disrupted circadian rhythms and mood disorders including major depressive disorder and neuroticism. The GWAS identified two gene regions that appear to be linked with disruption to rest-activity cycles. One of these contains a gene that inter- acts with a protein implicated in bipolar disorder (BD). Circadian rhythms are variations in cer- tain aspects of physiology and behavior— including body temperature, hormone release, concentration, mood, eating, and sleeping—which recur every 24 hours. Disruption in this rhythmicity has been linked with health problems ranging from cardiovascular disease, obesity, diabetes, and cancers, to major depressive disorder and BD, the authors write. n Adding Whole Strawberries to Diet Could Ward Off Gut Inflammation UMass researchers say that eating a bit less than a cup of strawberries per day could help mitigate colonic inflamma- tion and improve gut health. The re- searchers were interested in finding the berry's influence on gut health and inflammation associated with inflamma- tory bowel diseases (IBD) such as Crohn's disease and ulcerative colitis. Dietary consumption of fruits and veg- etables has been associated with a low- ered risk of IBD. To establish an effective and practical approach to decrease co- lonic inflammation in both IBD patients and the general population, the UMass team focused on strawberries due to their wide consumption. Decreased inflammation wasn't the strawberry's only conferred benefit not- ed by the researchers. Following the di- etary treatments of whole strawberries, the researchers observed a reversal of unhealthy microbiota composition in the IBD mice used for the study. n Fabio Pagani / EyeEm / Getty Images CRISTINA PEDRAZZINI/SCIENCE PHOTO LIBRARY / Getty Images mikroman6 / Getty Images

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