Clinical OMICS

JAN-FEB 2019

Healthcare magazine for research scientists, labs, pathologists, hospitals, cancer centers, physicians and biopharma companies providing news articles, expert interviews and videos about molecular diagnostics in precision medicine

Issue link: https://clinicalomics.epubxp.com/i/1071882

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News www.clinicalomics.com January/February 2019 Clinical OMICs 6 Mom's Prenatal Smoking Epigenetically Linked to Offspring's Obesity Studies by a University of Kentucky-led team suggest that maternal smoking in- creases levels of a protein called chem- erin—which is linked with obesity in adults—in their newborn babies. The findings, reported by Kevin Pearson, Ph.D., and colleagues in Experimental Physiol- ogy, suggest that smoking during preg- nancy may impact on epigenetic control of chemerin in the fetus and newborn, which then increases the risk of obesity later in life. In the U.S., nearly 35% of adults and 20% of children aged 6–19 years are obese, which costs the U.S. healthcare sys- tem some $200 billion annually. "Though multiple factors play a part in the devel- opment of obesity and metabolic disor- ders, one potential contribution is the in utero environment during pregnancy," the authors noted. n WuXi NextCODE Joins $400M Ireland Genomics R&D Hub WuXi NextCODE is investing in Irish life sciences company Genomics Medicine Ireland (GMI) as its Irish subsidiary. This is in order to partner with The Ireland Strate- gic Investment Fund (ISIF) on a $400 mil- lion initiative intended to position Ireland as a key hub for genomics research and development. WuXi NextCODE has com- mitted $225 million to GMI short-term, and potentially increase that investment to $400 million tied to achieving mile- stones as GMI expands. The initial investment will be designed to fund the expansion of GMI to carry out the sequencing of whole genomes from 400,000 volunteers, or 1 in every 10 peo- ple in Ireland, including patients with a range of common and rare diseases. The sequencing effort is planned to be one the world's largest whole genome se- quencing programs—joining initiatives launched by 10 nations toward gathering, storing, and applying genomic data from at least 100,000 genomes. n MRI Better than APOE4 at Predicting Alzheimer's Risk Washington University School of Medicine in St. Louis (WUSM) researchers presented data recently showing that MRI brain scans using diffusion tensor imaging (DTI) perform better than common clinical tests, such as those for the APOE4 gene, at predicting which people will go on to develop Alzheimer's disease. "Alzheimer's disease is the most common cause of dementia in the world and is expected to increase globally, and especially in the U.S., as the popula- tion gets older," explained lead study investiga- tor Cyrus Raji, M.D., Ph.D., assistant professor of radiology at the Mallinckrodt Institute of Radiology at WUSM. "As we develop new drug therapies and study them in trials, we need to identify individuals who will benefit from these drugs earlier in the course of the disease.". n @ Mariano Sayno / husayno.com / Getty Images PhotoAlto / Sigrid Olsson / PhotoAlto Agency RF Collections / Getty Images Alfred Pasieka / Science Photo Library / Getty Images

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