Clinical OMICS

MAR-APR 2019

Healthcare magazine for research scientists, labs, pathologists, hospitals, cancer centers, physicians and biopharma companies providing news articles, expert interviews and videos about molecular diagnostics in precision medicine

Issue link: https://clinicalomics.epubxp.com/i/1093879

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www.clinicalomics.com March/April 2019 Clinical OMICs 41 BraunS / Getty Images I n 2013, much of the world was introduced to the burgeon- ing field of precision medicine when world-famous actress, Angelina Jolie, announced she had undergone a double mastectomy to reduce her chances of getting breast cancer. With that announcement, things like BRCA genes, muta- tions, and proteins were thrust onto the public stage. Suddenly, precision medicine and predictive treatments weren't only being discussed in journals or at highly-tech- nical conferences, but on morning news shows and around water coolers. The notion that there was a way to possibly predict who's at risk for developing certain types of cancers was a bold and novel idea for most who are unfamiliar with the field. Simple single-gene and single-mutation models were the proverbial low hanging fruit, and were an initial onboard- ing to a new era of medicine. But ultimately, these have not been adequate as a predictive tool on a larger scale. We've made many technological advances, and have learned much through clinical studies and trials, yet we still seem focused on these remedial markers. Advancing wide- spread innovation in precision and predictive medicine, particularly in the fields of oncology and immuno-oncol- ogy, requires us to revisit this with an innovative approach. The Restrictive Cost of Drug Development Ultimately, what everyone wants is to deliver the right treat- ment to the right patient at the right time. This starts with drug development and ultimately with successful clinical trials. Yet, the cost of bringing a drug to market is ridicu- lously prohibitive, and selecting patients for clinical trials has become a major bottleneck. According to research from the Tufts Center for the Study of Drug Development, the cost of developing an approved drug exceeds $2.5 billion. Much of this cost is incurred during clinical trials. If the sheer logistics of conducting a clinical trial doesn't give you chills, the cost surely will. Simply finding the right patients for the trial incurs huge expense, and what happens when a patient ends up being excluded or isn't able to participate at the last minute? Replacing that patient incurs an even higher cost as a result of these delays. Drug development is also getting more expensive as clin- By David Messina, Ph.D. We Have the Tools to Advance Precision Medicine, Why Aren't We Using Them? (continued on next page) AlisaRut / iStock / Getty Images

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