Clinical OMICS

MAY-JUN 2019

Healthcare magazine for research scientists, labs, pathologists, hospitals, cancer centers, physicians and biopharma companies providing news articles, expert interviews and videos about molecular diagnostics in precision medicine

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Page 38 of 50 May/June 2019 Clinical OMICs 37 AI Data Insights Across the Precision Medicine Lifecycle Medidata has announced the launch of Acorn AI to provide actionable data insights across the entire precision medicine lifecycle—from R&D to commercialization. Built unpon the Medidata platform, Acorn AI is fueled by one of the largest regulatory-grade clinical data repositories in the world, com- prising more than 17,000 clinical trials (5,000 active) and the ability to analyze 45 billion patient re- cords from 2 million providers. It also includes the industry's largest structured, standardized clinical data repository with more than 4.8 million patients, serving more than 1,200 active customers with 150,000+ certified users. Acorn AI is developing new products such as a Value Discovery Engine to make better go/no-go decisions; Intelligent Trials to improve study suc- cess and speed; Integrated Evidence to help demonstrate value to regulators, payors, providers, and patients; and Connected Devices to integrate the new generation of medical devices within the digital healthcare ecosystem. Medidata On-Premises Diagnostic Decision Support In response to customers from government institutions, hospi- tals, and private research organizations, Congenica announced it now offers an on-premises deployment method in addition to cloud deployment for running its Sapientia platform. Pro- viding on-premises functionality allows for greater flexibility in how organizations control their platform and how the software is maintained, while still receiving the same functionally-rich platform capabilities. Sapientia provides clinicians with the ability upload NGS data in FASTQ, BAM, and VCF formats and then align and annotate SNVs and Indels and explore structural variants (SVs) and copy number variants (CNVs) while record- ing interpretation as per the ACMG guidelines for variant inter- pretation to speed diagnosis. Congenica Hallmarks of Cancer Aided Biomarker Discovery Almac Diagnostic Services launched the second iteration of claraT—a software solution, that classifies biologically relevant gene expression signatures using the Hallmarks of Cancer for easy interpretation. The updated version includes 62 gene expression signatures and 60 single-gene drug targets, in addition to nearly 4,000 other biology linked genes. Expanded content now includes six hallmark biologies: Avoiding Immune Destruction, Activating Invasion and Metastasis, Inducing Angiogenesis, Genome Insta- bility & Mutation, Sustaining Proliferative Signaling, and Resisting Cell Death. The company plans to continue to expand claraT re- porting to cover all 10 Hallmarks of Cancer by the end of the year. The company's proprietary bioinformatics pipelines provides a simplified report, helping to save time and maximize the under- standing of datasets more quickly. Almac Diagnostic Services Improved User-qPCR Instrument Interaction Thermo Fisher Scientific has launched what the company says are the first "smart" PCR instruments, its Applied Biosystems QuantStudio 6 and 7 Pro Real-Time PCR Systems. Added features for the Quant- Studio intruments include facial authentication, voice commands, radio-frequency identification (RFID)-enabled plate scanning, and single-touch access to product support. Facial authentication al- lows quick and secure log-in, and hands-free operation with voice-activated commands were added to improve user experience and productivity. The new system uses RFID-enabled Applied Biosystems TaqMan Array Plates for automated upload of plate layout and assay information for setting up the run, with results made available for remote analysis via desktop or via the mobile app. A Smart Help feature forwards system diagnostics to an on-call team member for issue diagnosis and, when possi- ble, remote service. Thermo Fisher Scientific New Products

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