Clinical OMICS

MAY-JUN 2018

Healthcare magazine for research scientists, labs, pathologists, hospitals, cancer centers, physicians and biopharma companies providing news articles, expert interviews and videos about molecular diagnostics in precision medicine

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Page 8 of 51 May/June 2018 Clinical OMICs 7 On St. Jude Cloud, researchers will be able to access whole genome data from more than 700 paired tumor/ germline samples for common and rare pediatric cancers, which was sequenced as part of the St. Jude Chil- dren's Research Hospital–Washington University Pediatric Cancer Genome Project. The interactive data-sharing platform allows scientists to explore more than 5,000 whole-genome, 5,000 whole-exome and 1,200 RNA-seq datasets from more than 5,000 pediat- ric cancer patients and survivors. St. Jude expects to make 10,000 whole-ge- nome sequences available on St. Jude Cloud by next year. According to St. Jude, the data on St. Jude Cloud is accessible by disease, publication, and curated dataset. A tool created by St. Jude, called PeCan data explorer, allows researchers to drill down into the samples. In addi- tion, researchers will also have access to a genomic visualization engine developed by St. Jude and a unique data browser that "allows friction- less navigation through the genome, including coding and non-coding regions." The goal was to make the platform "truly useful to regular researchers," Zhang said. "Nothing like this is avail- able in the world for regular research- ers with no computational skills." Zhang said both DNAnexus and Microsoft were selected for their unique skillsets and expertise—par- ticularly in privacy and security. "Data security on the cloud is extremely important, and we did not have the expertise to deal with this ourselves," she said. "Privacy is our number one concern." Researchers who apply to use St. Jude Cloud must consent to a series of federally mandated privacy protocols. "We believe that with the data being centralized on the cloud, it will pro- vide a better way of monitoring it," Zhang added. Microsoft has extensive experience in both the cloud and genomics. Mic- rosoft's cloud, Azure was launched in 2010. "We understand the complexi- ties of large-scale genomics data and are proud to say we've processed half a petabyte of data for St. Jude Cloud to date," said Geralyn Miller, director of Microsoft Genomics. "Microsoft has been involved in genomics for 12 years, with partners that include UC Santa Cruz Genomics Institute, Stanford Center for Genomics and Personalized Medicine, University of Medical Center Hamburg–Ependorf, and the University of Washington. Partners like DNAnexus, Curoverse, BC Platforms, and WuXi NextCODE have deployed platforms on Microsoft Azure to help manage, process and share genomic and biomedical data,." "The sheer scale of genomics data requires technology that can help researchers harness data in a more secure way," Miller said. "Micro- soft Azure is uniquely positioned to (continued on next page) Metabolon to Profile Samples in Million Veteran Program Metabolon said it will per- form large-scale metab- olomic profiling on bio- logical samples from U.S. veterans as part of the Mil- lion Veteran Program (MVP), through the company's part- nership with genomics ser- vices provider AKESOgen. MVP is designed to gather genetic data from up to 1 million vet- erans into a single database, in a study to advance knowledge about the links between genes and health. To date, nearly 640,000 vets have enrolled in the project, which collects and stores genet- ic, health, lifestyle, and military-exposure data gathered from questionnaires, medi- cal records, and omics analyses. "By combining the genetics data al- ready collected, the extensive clinical and lifestyle information that is unique to the VA healthcare system, and Metabolon's expertise in human metabolism, MVP aims to be one of the largest databases of its kind in the world," said Michael Gazia- no, M.D., an MVP principal investigator. n St. Jude Cloud will house the datasets of 10,000 WGS sequences by next year. Hilch / Getty Images

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